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. 1993;53(17):1353-6.
doi: 10.1016/0024-3205(93)90595-t.

Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells

P G Andreis  1 , C Tortorella, G G Nussdorfer
Affiliations

Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells

P G Andreis et al. Life Sci. 1993.

Abstract

Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland. Conversely PP did not affect either basal or ACTH- and angiotensin-II-stimulated aldosterone and corticosterone secretion of zona glomerulosa cells. These findings could throw light on the physiological significance of the marked increase in the pancreatic release of PP during stresses.

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