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Review
. 1993 Aug;64(8):539-44.

[Necrotizing myopathy with antilipemic agents. Case report and review of the literature]

[Article in German]
O Berger  1 , U Zifko, K Jellinger, E Machacek, W Grisold
Affiliations
  • PMID: 8413753
Review

[Necrotizing myopathy with antilipemic agents. Case report and review of the literature]

[Article in German]
O Berger et al. Nervenarzt. 1993 Aug.

Abstract

A 73 year old male who had been prescribed fenofibrate for years developed a slightly asymmetric paraparesis of both lower extremities. CPK values rose to 9800 U/l, EMG of the quadriceps femoris muscle was myopathic. Muscle biopsy revealed a necrotic myopathy. Discontinuation of fenofibrate induced a rapid decline of CPK values, followed by a slower remission of muscular symptoms and persisting pseudo-myotonic discharges in EMG. The spectrum of neuromuscular side effects of cholesterol lowering agents, consisting of myalgia, cramps and reversible CPK elevation, is discussed. Only rarely necrotic myopathies have been described.

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