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Comparative Study
. 1993 Jul;25(1):73-6.
doi: 10.1016/0143-4179(93)90072-i.

Effect of CCK-8 on audiogenic epileptic seizure in P77PMC rats

L X Zhang  1 , Y Zhou, Y Du, J S Han
Affiliations
Comparative Study

Effect of CCK-8 on audiogenic epileptic seizure in P77PMC rats

L X Zhang et al. Neuropeptides. 1993 Jul.

Abstract

P77PMC rat is a breed of rat with congenital audiogenic seizure(AS). AS attacks were suppressed by cholecystokinin octapeptide (CCK-8) injected intraperitoneally (i.p.) at a dose of 50 micrograms/kg, but not at 25 micrograms/kg. Radioimmunoassay study showed that the CCK-8 immunoreactivity (IR) in the cerebrocortex and hippocampus is much lower in P77PMC rats than that of Wistar rats. The results suggest that a low cerebral content of CCK-8 may account for the high susceptibility of audiogenic seizure in P77PMC rats.

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