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. 1993 Sep;43(9):1715-8.
doi: 10.1212/wnl.43.9.1715.

Botulinum antibodies in dystonic patients treated with type A botulinum toxin: frequency and significance

M Zuber  1 , M Sebald, N Bathien, J de Recondo, P Rondot
Affiliations

Botulinum antibodies in dystonic patients treated with type A botulinum toxin: frequency and significance

M Zuber et al. Neurology. 1993 Sep.

Abstract

We measured serum antibodies to botulinum toxin (ABT) in 96 patients with focal dystonia who had been treated with type A botulinum toxin. The frequency of detectable ABT was 3% (three patients). Patients with ABT had received more than 50 ng of botulinum toxin, and the shortest time between two injections was significantly less than in patients without ABT. The clinical evolution of the three patients was heterogeneous: one had decreased effectiveness with repeated injections, another had persistent improvement, and the third never responded to toxin injections.

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  • Antibodies to botulinum toxin.
    Borodic GE, Duane D, Pearce B, Johnson E. Borodic GE, et al. Neurology. 1995 Jan;45(1):204. doi: 10.1212/wnl.45.1.204. Neurology. 1995. PMID: 7880304 No abstract available.

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