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Case Reports
. 1993 Jan;305(1):36-9.
doi: 10.1097/00000441-199301000-00007.

Case report: acyclovir neurotoxicity and nephrotoxicity--the role for hemodialysis

B F Krieble  1 , D W Rudy, M R Glick, M D Clayman
Affiliations
Case Reports

Case report: acyclovir neurotoxicity and nephrotoxicity--the role for hemodialysis

B F Krieble et al. Am J Med Sci. 1993 Jan.

Abstract

Severe neurotoxicity and acute renal failure developed in a patient with newly diagnosed AIDS while receiving high-dosage intravenous acyclovir for disseminated herpes zoster. Hemodialysis resulted in a rapid resolution of neurologic symptoms and was associated with a reduction in plasma acyclovir concentration. Acute hemodialysis therapy should be considered in cases of serious neurotoxicity secondary to acyclovir, especially when accompanied by renal failure.

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