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Comparative Study
. 1979 Jan 27;1(8109):190-2.
doi: 10.1016/s0140-6736(79)90584-1.

Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides

J P Pandey, H H Fudenberg, G Virella, C U Kyong, C B Loadholt, R M Galbraith, E C Gotschlich, J C Parke Jr
Comparative Study

Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides

J P Pandey et al. Lancet. .

Abstract

Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera were allotyped for several Gm, A2m, and Km antigens. A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children.

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