[Effect of dibazol on cerebral blood supply and EEG in experimental intracerebral hemorrhage]

Abstract

A hemorrhage into the right internal capsule in vigilant cats is accompanied by a drop of focal cerebral blood flow in the sensomotor cortex, in the thalamus and reticular formation of the middle brain of both hemispheres, an appearance of slow-wave high amplitude in the EEG activity and in some cases of convulsive discharges. Such changes of the blood flow and bioelectrical activity are preserved in survived cats after 24 hours following hemorrhage. An intracarotid singular injection (Img/kg) and especially a 30 minute infusion of 0.5% solution of dibasol brings about in most of the cases an increase of the blood flow in the studied brain structures, and is accompanied by a partial normalization of bioelectrical activity.