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. 1993 Jan 15;123(1):81-6.
doi: 10.1016/0378-1119(93)90543-c.

A protein required for secretion of cholera toxin through the outer membrane of Vibrio cholerae

M Sandkvist  1 , V Morales, M Bagdasarian
Affiliations

A protein required for secretion of cholera toxin through the outer membrane of Vibrio cholerae

M Sandkvist et al. Gene. .

Abstract

A gene essential for the secretion of cholera toxin from the periplasm of Vibrio cholerae into the extracellular medium has been isolated and its nucleotide sequence determined. It encodes a cytoplasmic protein of 56 kDa that exhibits a high degree of similarity to gene products required for extracellular protein secretion in several other Gram- organisms. Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion.

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