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Comparative Study
. 1993 Jan 7;45(1):268-70.
doi: 10.1016/0006-2952(93)90403-j.

Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450

B J McDonald  1 , B M Bennett
Affiliations
Comparative Study

Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450

B J McDonald et al. Biochem Pharmacol. .

Abstract

Denitration of glyceryl trinitrate (GTN) by the microsomal fraction of rat aorta was found to be NADPH dependent and followed apparent first-order kinetics (T1/2 70.1 min). Biotransformation of GTN was regioselective for glyceryl-1,2-dinitrate formation, and was inhibited by carbon monoxide, SKF-525A, and oxygen. In aortic microsomes prepared from phenobarbital-pretreated rats, biotransformation was increased 7-fold, and was regioselective for glyceryl-1,3-dinitrate formation. These data strongly suggest the involvement of aortic cytochrome P450 in the biotransformation of GTN.

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