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Case Reports
. 1993 Feb;16(2):162-5.
doi: 10.1002/mus.880160207.

HTLV-1 in acquired adult myopathy

D J Dickoff  1 , D M Simpson, C A Wiley, S G Mendelson, J Farraye, D E Wolfe, W Wachsman
Affiliations
Case Reports

HTLV-1 in acquired adult myopathy

D J Dickoff et al. Muscle Nerve. 1993 Feb.

Abstract

We report a 53-year-old Jamaican man with 20 years of progressing weakness involving proximal limb muscles and neck flexors. Serum CK was 1100 IU/L. EMG demonstrated spontaneous activity, myopathic motor units, and full recruitment patterns in weak muscles. Muscle biopsy revealed marked myofiber degeneration with extensive fibrosis, suggesting a chronic myopathic process. HTLV-1 antibody was present in serum in high titers by ELISA and Western blot. Immunohistochemistry with rabbit polyclonal antisera to HTLV-1 showed rare staining myocytes. PCR demonstrated HTLV-1 DNA in frozen muscle tissue. This myopathy, associated with HTLV-1 infection, has clinical and pathological features similar to a dystrophy. We recommend serological screening for HTLV-1 in cryptogenic adult myopathies.

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