Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1993 Feb 1;90(3):1053-7.
doi: 10.1073/pnas.90.3.1053.

Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein

A Mukherjee  1 , K Dai, J Lutkenhaus
Affiliations
Comparative Study

Escherichia coli cell division protein FtsZ is a guanine nucleotide binding protein

A Mukherjee et al. Proc Natl Acad Sci U S A. .

Abstract

FtsZ is an essential cell division protein in Escherichia coli that forms a ring structure at the division site under cell cycle control. The dynamic nature of the FtsZ ring suggests possible similarities to eukaryotic filament forming proteins such as tubulin. In this study we have determined that FtsZ is a GTP/GDP binding protein with GTPase activity. A short segment of FtsZ is homologous to a segment in tubulin believed to be involved in the interaction between tubulin and guanine nucleotides. A lethal ftsZ mutation, ftsZ3 (Rsa), that leads to an amino acid alteration in this homologous segment decreased GTP binding and hydrolysis, suggesting that interaction with GTP is essential for ftsZ function.

PubMed Disclaimer

References

    1. Science. 1972 Sep 22;177(4054):1104-5 - PubMed
    1. J Bacteriol. 1992 Aug;174(16):5414-23 - PubMed
    1. J Biol Chem. 1979 Dec 10;254(23):11982-7 - PubMed
    1. Mol Cell Biochem. 1982 Sep 3;47(2):97-113 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Mar;80(5):1232-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources