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. 1993 Jan;37(1):128-9.
doi: 10.1128/AAC.37.1.128.

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

A A Neyfakh  1 , C M Borsch, G W Kaatz
Affiliations

Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter

A A Neyfakh et al. Antimicrob Agents Chemother. 1993 Jan.

Abstract

The gene of the Staphylococcus aureus fluoroquinolone efflux transporter protein NorA confers resistance to a number of structurally dissimilar drugs, not just to fluoroquinolones, when it is expressed in Bacillus subtilis. NorA provides B. subtilis with resistance to the same drugs and to a similar extent as the B. subtilis multidrug transporter protein Bmr does. NorA and Bmr share 44% sequence similarity. Both the NorA- and Bmr-conferred resistances can be completely reversed by reserpine.

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References

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