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. 1993 Jan;15(1):219-21.
doi: 10.1006/geno.1993.1040.

Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2

H Yu  1 , R Thun, S Chandrasekharappa, J M Trent, J Zhang, M H Meisler
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Free article

Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2

H Yu et al. Genomics. 1993 Jan.
Free article

Abstract

Cytoplasmic liver phosphoenolpyruvate carboxykinase (GTP) (PEPCK) catalyzes a rate-limiting step in gluconeogenesis. Primers derived from the rat liver PEPCK sequence were used to amplify a portion of the human liver cDNA and to screen a YAC library of human genomic DNA. The sequences of human and rat PEPCK cDNA differed at 16% of the nucleotides compared (45/291). Analysis of a human/rodent hybrid mapping panel demonstrated concordant segregation of PCK1 with chromosome 20. Fluorescence in situ hybridization with YAC DNA further localized PCK1 to subband 20q13.2.

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