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Review
. 1978 Dec;65(12):616-39.
doi: 10.1007/BF00401905.

Genetic determination of antibody specificity. Gene translocation and fusion, the molecular basis for the differentiation of the antibody-producing cell

N Hilschmann, H U Barnikol, H Kratzin, P Altevogt, M Engelhard, S Barnikol-Watanabe
Review

Genetic determination of antibody specificity. Gene translocation and fusion, the molecular basis for the differentiation of the antibody-producing cell

N Hilschmann et al. Naturwissenschaften. 1978 Dec.

Abstract

The best system for the study of cell differentiation is a cell which in its differentiated state differs only by one product. This is the case in the immune system. The undifferentiated, but omnipotent stem cell differentiates into a committed B cell which produces only one type of specific antibody out of a million different, genetically fixed possibilities. Gene translocation and fusion is the basis of this differentiation process.

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