Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Mar;17(3):269-74.
doi: 10.1016/S0006-3495(77)85655-5.

Evidence that nystatin may not form channels in thin lipid membranes

W O Romine, G R Sherette, G B Brown, R J Bradley

Evidence that nystatin may not form channels in thin lipid membranes

W O Romine et al. Biophys J. 1977 Mar.

Abstract

The mechanism of nystatin-induced conductance increases in planar bilayer membranes formed from lecithin/cholesterol (1:1) has been examined by spectral analysis of kinetic fluctuations. Lorentzian components of the power spectrum, characteristic of channel activity, were not observed for nystatin-doped membranes. Instead, the noise associated with this system (approximately 10(-27)A2/Hz) was in better agreement with that expected of a carrier mechanism involved in the transport of single charges in uncorrelated fashion. The implications of this result with respect to previous models of nystatin-induced conductance increases are discussed.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Prog Biophys Mol Biol. 1974;28:189-265 - PubMed
    1. Ann N Y Acad Sci. 1975 Dec 30;264:247-64 - PubMed
    1. Biochim Biophys Acta. 1974 Feb 26;339(1):57-70 - PubMed
    1. Nature. 1970 Jan 31;225(5231):451-3 - PubMed
    1. Biochim Biophys Acta. 1976 Mar 19;426(3):447-50 - PubMed

Publication types

LinkOut - more resources