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. 1977 Mar;17(3):269-74.
doi: 10.1016/S0006-3495(77)85655-5.

Evidence that nystatin may not form channels in thin lipid membranes

W O Romine, G R Sherette, G B Brown, R J Bradley

Evidence that nystatin may not form channels in thin lipid membranes

W O Romine et al. Biophys J. 1977 Mar.

Abstract

The mechanism of nystatin-induced conductance increases in planar bilayer membranes formed from lecithin/cholesterol (1:1) has been examined by spectral analysis of kinetic fluctuations. Lorentzian components of the power spectrum, characteristic of channel activity, were not observed for nystatin-doped membranes. Instead, the noise associated with this system (approximately 10(-27)A2/Hz) was in better agreement with that expected of a carrier mechanism involved in the transport of single charges in uncorrelated fashion. The implications of this result with respect to previous models of nystatin-induced conductance increases are discussed.

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References

    1. Prog Biophys Mol Biol. 1974;28:189-265 - PubMed
    1. Ann N Y Acad Sci. 1975 Dec 30;264:247-64 - PubMed
    1. Biochim Biophys Acta. 1974 Feb 26;339(1):57-70 - PubMed
    1. Nature. 1970 Jan 31;225(5231):451-3 - PubMed
    1. Biochim Biophys Acta. 1976 Mar 19;426(3):447-50 - PubMed

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