Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Feb;133(2):143-8.
doi: 10.1093/genetics/133.2.143.

The effects of central asymmetry on the propagation of palindromic DNA in bacteriophage lambda are consistent with cruciform extrusion in vivo

A F Chalker  1 , E A Okely, A Davison, D R Leach
Affiliations

The effects of central asymmetry on the propagation of palindromic DNA in bacteriophage lambda are consistent with cruciform extrusion in vivo

A F Chalker et al. Genetics. 1993 Feb.

Abstract

The propagation of lambda phages carrying long perfect palindromes has been compared with that of phages carrying imperfect palindromes with small regions of central asymmetry. The perfect palindromes confer a more deleterious phenotype than those with central asymmetry and the severity of the phenotype declines with the length of asymmetry in the range from O to 27 base pairs. These results argue that a center-dependent reaction is involved in the phenotypic effects of palindromic DNA sequences, consistent with the idea that cruciform extrusion occurs in vivo.

PubMed Disclaimer

References

    1. J Mol Biol. 1989 Apr 20;206(4):779-82 - PubMed
    1. Gene. 1988 Aug 15;68(1):139-49 - PubMed
    1. J Bacteriol. 1991 Apr;173(8):2658-64 - PubMed
    1. J Mol Biol. 1991 Sep 5;221(1):107-22 - PubMed
    1. J Bacteriol. 1992 Feb;174(4):1222-8 - PubMed

Publication types