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Case Reports
. 1993 Feb;43(2):421-4.
doi: 10.1212/wnl.43.2.421.

Nonketotic hyperglycinemia: clinical and electrophysiologic effects of dextromethorphan, an antagonist of the NMDA receptor

B Schmitt  1 , B Steinmann, R Gitzelmann, L Thun-Hohenstein, H Mascher, G Dumermuth
Affiliations
Case Reports

Nonketotic hyperglycinemia: clinical and electrophysiologic effects of dextromethorphan, an antagonist of the NMDA receptor

B Schmitt et al. Neurology. 1993 Feb.

Abstract

A 10-week-old girl with nonketotic hyperglycinemia was treated with increasing amounts of dextromethorphan, an NMDA receptor antagonist. She improved neurologically; at 35 mg/kg/d, seizures ceased and EEG normalized. Dextromethorphan withdrawal resulted in a dramatic clinical deterioration coinciding with epileptic and high-voltage slow activity in the EEG. After reintroduction of dextromethorphan (35 mg/kg/d), recovery occurred within 24 hours.

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