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. 1993 Feb 20;1172(1-2):220-2.
doi: 10.1016/0167-4781(93)90300-3.

Determination of mouse major asialoglycoprotein receptor cDNA sequence

R Takezawa  1 , K Shinzawa, Y Watanabe, T Akaike
Affiliations

Determination of mouse major asialoglycoprotein receptor cDNA sequence

R Takezawa et al. Biochim Biophys Acta. .

Abstract

Hepatic lectins (asialoglycoprotein receptors) specifically recognize galactose-terminated glycoproteins and mediate endocytosis of these molecules. We now report the cloning and sequence of a cDNA encoding murine asialoglycoprotein receptor. It shows high homology with rat and human major receptor forms designated RHL-1 and HHL-1, respectively. They have many conserved regions, such as a transmembrane region, carbohydrate additional region and carbohydrate related region. According to the homology analysis, we concluded that the clone encodes the mouse major asialoglycoprotein receptor (MHL-1).

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