doi: 10.1139/y77-020.
Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex
- PMID: 843988
- DOI: 10.1139/y77-020
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Metergoline as a selective 5-hydroxytryptamine antagonist in the cerebral cortex
Can J Physiol Pharmacol.
1977 Feb.
Abstract
In rats anaesthetized with a mixture of methoxyflurane, nitrous oxide, and oxygen, the depressant actions on the cerebral cortical neurones of iotophoretically applied 5-hydroxytryptamine (5-HT) but not of noradrenaline, histamine, AMP Ca2+, and gamma-aminobutyric acid were antagonized by metergoline. These observations indicate that metergoline may be a selective 5-HT antagonist in the cerebral cortex.
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