Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jan 11;21(1):27-36.
doi: 10.1093/nar/21.1.27.

Telomere directed fragmentation of mammalian chromosomes

M A Barnett  1 , V J Buckle, E P Evans, A C Porter, D Rout, A G Smith, W R Brown
Affiliations
Free PMC article

Telomere directed fragmentation of mammalian chromosomes

M A Barnett et al. Nucleic Acids Res. .
Free PMC article

Abstract

Cloned human telomeric DNA can integrate into mammalian chromosomes and seed the formation of new telomeres. This process occurs efficiently in three established human cell lines and in a mouse embryonic stem cell line. The newly seeded telomeres appear to be healed by telomerase. The seeding of new telomeres by cloned telomeric DNA is either undetectable or very inefficient in non-tumourigenic mouse or human somatic cell lines. The cytogenetic consequences of the seeding of new telomeres include large chromosome truncations but most of the telomere seeding events occur close to the pre-existing ends of natural chromosomes.

PubMed Disclaimer

References

    1. Cancer Res. 1973 Dec;33(12):3231-8 - PubMed
    1. J Exp Med. 1953 May;97(5):695-710 - PubMed
    1. Science. 1980 Sep 19;209(4463):1422-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 Apr;82(7):2106-10 - PubMed
    1. Cytogenet Cell Genet. 1987;44(2-3):65-8 - PubMed

Publication types