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Review
. 1993 Feb 11;21(3):365-72.
doi: 10.1093/nar/21.3.365.

DNA sequences at immunoglobulin switch region recombination sites

W Dunnick  1 , G Z Hertz, L Scappino, C Gritzmacher
Affiliations
Free PMC article
Review

DNA sequences at immunoglobulin switch region recombination sites

W Dunnick et al. Nucleic Acids Res. .
Free PMC article

Erratum in

  • Nucleic Acids Res 1993 May 11;21(9):2285

Abstract

The immunoglobulin heavy chain switch from synthesis of IgM to IgG, IgA or IgE is mediated by a DNA recombination event. Recombination occurs within switch regions, 2-10 kb segments of DNA that lie upstream of heavy chain constant region genes. A compilation of DNA sequences at more than 150 recombination sites within heavy chain switch regions is presented. Switch recombination does not appear to occur by homologous recombination. An extensive search for a recognition motif failed to find such a sequence, implying that switch recombination is not a site-specific event. A model for switch recombination that involves illegitimate priming of one switch region on another, followed by error-prone DNA synthesis, is proposed.

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