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. 1993 Feb 11;21(3):455-61.
doi: 10.1093/nar/21.3.455.

Functional analysis of the human neurofilament light chain gene promoter

K Yazdanbakhsh  1 , P Fraser, D Kioussis, M Vidal, F Grosveld, M Lindenbaum
Affiliations
Free PMC article

Functional analysis of the human neurofilament light chain gene promoter

K Yazdanbakhsh et al. Nucleic Acids Res. .
Free PMC article

Abstract

We have carried out a structural and functional analysis on the human NF-L (H-NF-L) gene. It contains a methylation-free island, spanning the 5' flanking sequences and the first exon and a number of neuronal-specific DNase I hypersensitive sites have been identified in the upstream region as well as within the body of the gene. Analysis in cell lines and transgenic mice using a combination of these sites has revealed the presence of a conserved element(s) between -300bp and -190bp which is required for neuronal-specific expression.

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