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Comparative Study
. 1993 Feb 11;21(3):561-8.
doi: 10.1093/nar/21.3.561.

BI-BII transitions in B-DNA

B Hartmann  1 , D Piazzola, R Lavery
Affiliations
Free PMC article
Comparative Study

BI-BII transitions in B-DNA

B Hartmann et al. Nucleic Acids Res. .
Free PMC article

Abstract

Molecular modelling is used to study the conformational and energetic aspects of BI-BII transitions within the backbone of a B-DNA dodecamer d(CATGACGTCATG) whose fine structure has previously been determined by molecular modelling combined with NMR spectroscopy. It is shown that while the dodecamer under investigation does not contain any BII junctions, the central CpG step can most easily undergo the transition. More generally, it is also found that the base sequence and hence the backbone geometry of a DNA segment, strongly influences both the conformational impact of the transition, the associated energy barrier and the stability of the resulting BII state.

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References

    1. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6486-90 - PubMed
    1. J Biomol Struct Dyn. 1992 Feb;9(4):681-93 - PubMed
    1. Science. 1987 Oct 23;238(4826):498-504 - PubMed
    1. Proc Natl Acad Sci U S A. 1988 Oct;85(19):7231-5 - PubMed
    1. J Mol Biol. 1989 Feb 20;205(4):787-91 - PubMed

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