Multiple levels of peripheral tolerance
- PMID: 8442855
- DOI: 10.1016/0167-5699(93)90317-E
Multiple levels of peripheral tolerance
Abstract
The establishment and maintenance of self tolerance is based on multiple events in the thymus and periphery, resulting in either deletion of self-reactive T cells or induction of nonresponsiveness. Here, Bernd Arnold and colleagues propose that, depending on the tolerogenic signals, peripheral T cells can reach different levels of tolerance with regard to their capacity for reactivation. In addition, it appears that tolerant T cells are still susceptible to further tolerogenic signals, driving them into a deeper state of tolerance. Thus, induction of T-cell tolerance can be viewed as a multistep mechanism.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources