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. 1993 Feb 28;124(2):245-9.
doi: 10.1016/0378-1119(93)90400-w.

Cloning and characterisation of the gene encoding the 28-kDa glutathione S-transferase of Schistosoma mansoni

A T McNair  1 , C Dissous, O Duvaux-Miret, A Capron
Affiliations

Cloning and characterisation of the gene encoding the 28-kDa glutathione S-transferase of Schistosoma mansoni

A T McNair et al. Gene. .

Abstract

The 28-kDa glutathione S-transferase (GST) of Schistosoma mansoni is considered a possible vaccine candidate for use against this medically important parasite. The gene encoding this molecule has been isolated from a lambda EMBL4 library by using the corresponding cDNA sequence as a probe. The gene contains four exons and is approximately 5.5 kb in length. Analysis of the 5' flanking region revealed the presence of a consensus AP-1 recognition site, 5'-TGACTCA, between nucleotides -231 and -225. Southern blot analysis suggested the presence of a single gene encoding the 28-kDa GST in the S. mansoni genome.

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