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. 1993 Jan;16(1):65-8.
doi: 10.1007/BF03345834.

In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues

A Bogdan  1 , A Auzéby, P F Plouin, Y Touitou
Affiliations

In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues

A Bogdan et al. J Endocrinol Invest. 1993 Jan.

Abstract

The in vitro metabolism of [1,2-3H] deoxycorticosterone (DOC), [1,2-3H] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-3H] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability.

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