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Case Reports
. 1993 Feb;52(2):158-60.
doi: 10.1136/ard.52.2.158.

Systemic amyloidosis AL with temporal artery involvement revealing lymphoplasmacytic malignancy in a man presenting as polymyalgia rheumatica

P Lafforgue  1 , E Senbel, D Figarella-Branger, J Boucraut, N Horschowsky, J F Pellissier, P C Acquaviva
Affiliations
Case Reports

Systemic amyloidosis AL with temporal artery involvement revealing lymphoplasmacytic malignancy in a man presenting as polymyalgia rheumatica

P Lafforgue et al. Ann Rheum Dis. 1993 Feb.

Abstract

A 68 year old man presented with a clinical and biological picture that suggested polymyalgia rheumatica. Temporal artery biopsy disclosed no inflammatory change but massive light chain amyloid deposits in the media. Further exploration showed a malignant lymphoplasmacytic haemopathy with a triclonal gammopathy and a muscular, rectal, and probable cardiac amyloidosis. Cryoglobulinaemia and high concentrations of soluble interleukin 2 receptor (sIL-2R) were also found. This is the fifth case with confirmed involvement of the temporal artery. The especially high sIL-2R concentration was thought to reflect the tumour mass rather than lymphocyte activation.

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