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Review
. 1993 Feb;3(1):5-10.
doi: 10.1016/s0959-437x(05)80334-x.

Cyclin D and oncogenesis

T Motokura  1 , A Arnold
Affiliations
Review

Cyclin D and oncogenesis

T Motokura et al. Curr Opin Genet Dev. 1993 Feb.

Abstract

The D-type cyclins are among the candidate 'G1 cyclins' in higher eukaryotes that may regulate G1-S-phase progression. The human cyclin D1 gene, also known as PRAD1 (and previously as D11S287), is a putative proto-oncogene strongly implicated in several types of human tumors, including parathyroid adenomas, B-cell neoplasms (as the 'BCL-1 oncogene'), and breast and squamous cell cancers. The mechanism by which deregulated production of cyclin D1/PRAD1, and perhaps other D-type cyclins, contributes to tumor development is only beginning to be deciphered.

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