Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Mar 25;268(9):6615-21.

Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype

R Wadhwa  1 , S C Kaul, Y Ikawa, Y Sugimoto
Affiliations
  • PMID: 8454632
Free article

Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype

R Wadhwa et al. J Biol Chem. .
Free article

Abstract

A novel 66-kDa protein, named p66mot-1, is identified to be associated with cellular mortality by virtue of its presence in cytosolic fractions of serially passaged mouse embryonic fibroblasts (MEF) and the mortal hybrids obtained by the fusion of mortal (MEF) and immortal (MN48-1, derivative of NIH 3T3) cells. Immortal cells lack this protein in their cytosolic fractions. cDNA cloning and homology search placed it in the heat shock protein 70 (hsp70) family. Microinjection of anti-p66 antibody to senescent MEF could transiently stimulate their cell division, which supports the cellular mortality-related function of p66mot-1.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources