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Clinical Trial
. 1993 Mar;168(3 Pt 1):824-30.
doi: 10.1016/s0002-9378(12)90828-5.

Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: a double-blind placebo-controlled study

I Wiklund  1 , J Karlberg, L A Mattsson
Affiliations
Clinical Trial

Quality of life of postmenopausal women on a regimen of transdermal estradiol therapy: a double-blind placebo-controlled study

I Wiklund et al. Am J Obstet Gynecol. 1993 Mar.

Abstract

Objective: The effect of transdermal estradiol and placebo therapy on the quality of life of postmenopausal women was compared in a randomized trial over 12 weeks.

Study design: Two hundred forty-two women were randomized, and 223 were analyzed for efficacy (n = 112 for estradiol and n = 111 for placebo). The quality of life was assessed by means of a battery of standard questionnaires.

Results: Quality of life improved after both therapies, but health-related quality of life (p = 0.0003) and well being (p = 0.003) improved more after transdermal estradiol therapy than after placebo. This was also the case for all specific climacteric aspects, including sexual problems (p < 0.0001) and dysfunction (p = 0.01), at comparison with placebo. Self-rated symptom relief was more pronounced with estrogen therapy than with placebo (p < 0.0001).

Conclusion: It was concluded that estradiol therapy was superior to placebo in relieving symptoms and improving quality of life.

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