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Clinical Trial
. 1993 Mar-Apr;39(2):147-52.
doi: 10.1159/000239118.

Ceftriaxone plus conventional or single-daily dose amikacin versus ceftazidime/amikacin as empiric therapy in febrile neutropenic patients

F Leoni  1 , S Ciolli, A Pascarella, R Fanci, R Caporale, P Rossi Ferrini
Affiliations
Clinical Trial

Ceftriaxone plus conventional or single-daily dose amikacin versus ceftazidime/amikacin as empiric therapy in febrile neutropenic patients

F Leoni et al. Chemotherapy. 1993 Mar-Apr.

Abstract

Results of antibiotic treatment in 144 febrile episodes during drug-induced granulocytopenia are reported. 63 episodes were treated with ceftazidime plus amikacin and 81 with ceftriaxone (CFX) using single daily doses combined with amikacin either divided in three doses (CFX-1 group) or administered as single doses (CFX-2 group). The response rates were 51, 80, and 57% respectively. In this study CFX was more effective than ceftazidime and amikacin provided better results when administered using the standard 8-hour scheduling.

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