Comparative Study
doi: 10.1021/jm00213a012.
Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids
- PMID: 845870
- DOI: 10.1021/jm00213a012
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Comparative Study
Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids
J Med Chem.
1977 Mar.
Abstract
A series of substituted chromone-2-carboxylic acids was synthesized and tested as antagonists of SRS-A induced contractions of isolated guinea pig ileum. This work led to the discovery of sodium 7-[3-(4-acetyl-3hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (FPL 55712) which is the first reported specific antagonist of SRS-A. Some structural requirements for biological activity within this series are discussed.
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