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Comparative Study
. 1977 Mar;20(3):371-9.
doi: 10.1021/jm00213a012.

Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids

R A Appleton, J R Bantick, T R Chamberlain, D N Hardern, T B Lee, A D Pratt
Comparative Study

Antagonists of slow reacting substance of anaphylaxis. Synthesis of a series of chromone-2-carboxylic acids

R A Appleton et al. J Med Chem. 1977 Mar.

Abstract

A series of substituted chromone-2-carboxylic acids was synthesized and tested as antagonists of SRS-A induced contractions of isolated guinea pig ileum. This work led to the discovery of sodium 7-[3-(4-acetyl-3hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate (FPL 55712) which is the first reported specific antagonist of SRS-A. Some structural requirements for biological activity within this series are discussed.

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