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. 1993 Apr 1;177(4):1153-64.
doi: 10.1084/jem.177.4.1153.

Thymus epithelium induces tissue-specific tolerance

A Bonomo  1 , P Matzinger
Affiliations

Thymus epithelium induces tissue-specific tolerance

A Bonomo et al. J Exp Med. .

Abstract

Most current models of T cell development include a positive selection step in the thymus that occurs when T cells interact with thymic epithelium and a negative selection step after encounters with bone marrow-derived cells. We show here that developing T cells are tolerized when they recognize antigens expressed by thymic epithelium, that the tolerance is tissue specific, and that it can occur by deletion of the reactive T cells.

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