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. 1993 Apr 1;177(4):891-6.
doi: 10.1084/jem.177.4.891.

The life span of naive alpha/beta T cells in secondary lymphoid organs

H von Boehmer  1 , K Hafen
Affiliations

The life span of naive alpha/beta T cells in secondary lymphoid organs

H von Boehmer et al. J Exp Med. .

Abstract

We have determined the life span of naive CD4-8+ T cells in T cell receptor transgenic mice. We find that such cells do not divide in secondary lymphoid organs in both normal euthymic mice and T cell-deficient mice. By both continuous labeling and by chasing pulse-labeled cells, we find that the minimum life span of the naive T cells is in the order of 8 wk.

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