Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Mar;56(3):298-300.
doi: 10.1136/jnnp.56.3.298.

An epidemiological study of Wilson's disease in the Republic of Ireland

M Reilly  1 , L Daly, M Hutchinson
Affiliations

An epidemiological study of Wilson's disease in the Republic of Ireland

M Reilly et al. J Neurol Neurosurg Psychiatry. 1993 Mar.

Abstract

In a population based study of the prevalence of Wilson's disease in the Republic of Ireland from 1970-89, 26 definite and probable cases were ascertained. The adjusted birth incidence rate was 17.0 per million live births (95% (confidence interval 9.9 to 27.2)) for the 20 year period 1950-69. The gene frequency was 0.41% (95% (confidence interval 0.31% to 0.52%) indicating that one in 122 of the population was a gene carrier. Allowing for a maximal degree of consanguinity, the gene frequency is reduced to 0.36% and the proportion of heterozygotes to one in 139 of the population. The consistency of the adjusted birth incidence rates over the decades 1950-59 and 1960-69 suggests a high degree of ascertainment of diagnosed cases of Wilson's disease.

PubMed Disclaimer

References

    1. Ann Hum Genet. 1990 May;54(Pt 2):155-68 - PubMed
    1. Am J Med. 1953 Oct;15(4):442-9 - PubMed
    1. Tohoku J Exp Med. 1965 Mar 25;85:115-9 - PubMed
    1. Acta Neurol Scand. 1969;45(1):114-8 - PubMed
    1. Q J Med. 1987 Dec;65(248):959-66 - PubMed