Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1993 Mar;86(3):137-8.
doi: 10.1177/014107689308600306.

Postoperative nausea and vomiting: a comparison of anti-emetic drugs used alone or in combination

D Michaloudis  1 , N O'Keeffe, K O'Sullivan, T E Healy
Affiliations
Clinical Trial

Postoperative nausea and vomiting: a comparison of anti-emetic drugs used alone or in combination

D Michaloudis et al. J R Soc Med. 1993 Mar.

Abstract

Drugs with anti-emetic properties can exert their actions at more than one receptor site, histamine H1, muscarinic cholinergic or dopaminergic D2 receptors. This study was designed to test the hypothesis that a combination of drugs acting at different receptor sites in lower than standard doses would be at least as effective as a standard therapeutic dose of a single anti-emetic agent. A combination of droperidol, hyoscine and metoclopramide in subtherapeutic doses has been shown to be at least as effective as droperidol (1.25 mg) alone. In both groups there was a low incidence of emetic sequelae in the first 3 hours postoperatively.

PubMed Disclaimer

References

    1. Br J Anaesth. 1984 Jan;56(1):19-27 - PubMed
    1. Anesthesiology. 1960 Mar-Apr;21:186-93 - PubMed
    1. Acta Anaesthesiol Scand. 1982 Feb;26(1):48-52 - PubMed
    1. Eur J Anaesthesiol. 1986 Jan;3(1):1-9 - PubMed
    1. Anesth Analg. 1981 Nov;60(11):783-8 - PubMed