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. 1993 Apr;52(4):736-42.

A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

J Feunteun  1 , S A Narod, H T Lynch, P Watson, T Conway, J Lynch, J Parboosingh, P O'Connell, R White, G M Lenoir
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A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

J Feunteun et al. Am J Hum Genet. 1993 Apr.

Abstract

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.

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