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Clinical Trial
. 1993 Feb;48(2):111-3.
doi: 10.1111/j.1365-2044.1993.tb06846.x.

Propofol and fentanyl act additively for induction of anaesthesia

I Ben-Shlomo  1 , J Finger, E Bar-Av, A Z Perl, A Etchin, M Tverskoy
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Free article
Clinical Trial

Propofol and fentanyl act additively for induction of anaesthesia

I Ben-Shlomo et al. Anaesthesia. 1993 Feb.
Free article

Abstract

The induction dose-response of propofol was compared with the dose-response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 women undergoing minor gynaecological surgery. Dose-response curves were determined for each group using bootstrap and isobolographic analyses. Propofol was found to act additively with fentanyl for induction of anaesthesia. Twenty-three percent of the ED50 of fentanyl was required in combination with 75% of the ED50 for propofol to achieve the ED50 of the combination. This indicates that, for induction of anaesthesia, propofol and fentanyl are not synergistic.

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