Review
doi: 10.1016/0190-9622(93)70072-2.
Systemic sclerosis
Affiliations
- PMID: 8463454
- DOI: 10.1016/0190-9622(93)70072-2
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Review
Systemic sclerosis
J Am Acad Dermatol.
1993 Apr.
Abstract
Systemic sclerosis affects the connective tissue of various organs. It is characterized by alteration of the microvasculature with a dense inflammatory cellular infiltrate, followed by massive deposition of collagen. This review discusses diagnostic criteria, clinical subsets, survival data, clinical evaluation, epidemiology, pathogenesis, immunobiology, genetics, and therapy for systemic sclerosis in adults. Because the diagnosis of systemic sclerosis is most dependent on its cutaneous involvement, knowledge of this is essential in the evaluation and management of patients with this disorder.
Comment in
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The use of pentoxifylline in the treatment of systemic sclerosis and lipodermatosclerosis: a unifying hypothesis?J Am Acad Dermatol. 1994 Jul;31(1):135-6. doi: 10.1016/s0190-9622(09)80258-2. J Am Acad Dermatol. 1994. PMID: 8054069 No abstract available.
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Cutaneous and plasma fibrinolytic activities are not deficient in patients with systemic sclerosis.J Am Acad Dermatol. 1994 May;30(5 Pt 1):813-4. doi: 10.1016/s0190-9622(08)81531-9. J Am Acad Dermatol. 1994. PMID: 8176033 No abstract available.
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