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Comparative Study
. 1993 Mar 31;191(3):880-6.
doi: 10.1006/bbrc.1993.1299.

The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure

M J Hoffer  1 , M M van Eck, F Petrij, A van der Zee, E de Wit, D Meijer, G Grosveld, L M Havekes, M H Hofker, R R Frants
Affiliations
Comparative Study

The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure

M J Hoffer et al. Biochem Biophys Res Commun. .

Abstract

The low density lipoprotein (LDL) receptor plays a central role in the cholesterol metabolism. The cDNA sequence of the mouse low density lipoprotein receptor (Ldlr) gene has been determined and shows 76% homology with the human gene. The exon-intron structure has been determined for the 129/J mouse strain. The gene is composed of 18 exons and spans a region of 28 kb. In addition, the promoter regions of the mouse and human genes are homologous. Northern blot analysis revealed an mRNA of approximately 5 kb. The cloning of the Ldlr gene will enhance the usefulness of the mouse for the study of cholesterol metabolism and, in particular, for carrying out gene targeting experiments.

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