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Review
. 1993 May 1;71(9):2847-53.
doi: 10.1002/1097-0142(19930501)71:9<2847::aid-cncr2820710928>3.0.co;2-e.

Bone tumors other than osteosarcoma after retinoblastoma

K J Helton  1 , B D Fletcher, L E Kun, J J Jenkins 3rd, C B Pratt
Affiliations
Review

Bone tumors other than osteosarcoma after retinoblastoma

K J Helton et al. Cancer. .

Abstract

Background: The most frequent second malignant neoplasm after retinoblastoma is osteosarcoma, which may be associated with radiation therapy or arise de novo in patients with bilateral retinoblastoma.

Methods: Clinical, pathologic, and diagnostic imaging findings in two patients with Ewing sarcoma (ES) and one with peripheral neuroepithelioma (PN) are presented.

Results: Second malignant neoplasms located in the extremities or pelvis were seen 12-18 years after initial diagnosis of unilateral (two patients) or bilateral (one patient) retinoblastoma. The patients with unilateral retinoblastoma were treated by enucleation only; the other received ocular radiation therapy and chemotherapy. To the knowledge of the authors, this is the first documentation of round blue cell tumor after unilateral retinoblastoma.

Conclusions: ES and PN should be included in the differential diagnosis of malignant neoplasms occurring after treatment of unilateral or bilateral retinoblastoma.

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