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. 1977 Apr;11(4):303-5.
doi: 10.1203/00006450-197704000-00009.

Effect of 4-pentenoate on rat liver ornithine transcarbamylase

A M Glasgow

Effect of 4-pentenoate on rat liver ornithine transcarbamylase

A M Glasgow. Pediatr Res. 1977 Apr.

Abstract

The effect of 4-pentenoate on rat liver ornithine transcarbamylase was studied. No effect was found. It is concluded that the effect of 4-pentenoic acid on ornithine transcarbamylase reported by others was probably due to technical errors. Available evidence indicates that 4-pentenoate inhibits ureagenesis by interfering with mitochondrial energy metabolism, which in turn impairs mitochondrial ornithine transport or depletes mitochondrial ATP, impairing carbamyl phosphate synthesis, or both.

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