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. 1993 Feb;46(2):222-8.
doi: 10.7164/antibiotics.46.222.

Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity

S Omura  1 , D Van der Pyl, J Inokoshi, Y Takahashi, H Takeshima
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Free article

Pepticinnamins, new farnesyl-protein transferase inhibitors produced by an actinomycete. I. Producing strain, fermentation, isolation and biological activity

S Omura et al. J Antibiot (Tokyo). 1993 Feb.
Free article

Abstract

Pepticinnamins A, B, C, D, E and F, a family of farnesyl-protein transferase (FPT) inhibitors were isolated from the fermentation broth of Streptomyces sp. OH-4652. These inhibitors were purified from whole broth by extraction with chloroform, followed by silica gel column chromatography, Sephadex LH-20 chromatography and reverse phase HPLC. Among these, pepticinnamin C showed the most potent inhibition (IC50-100 nM).

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