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. 1993 Apr 22;362(6422):722-8.
doi: 10.1038/362722a0.

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

N C Andrews  1 , H Erdjument-Bromage, M B Davidson, P Tempst, S H Orkin
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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein

N C Andrews et al. Nature. .

Abstract

Expression of globin genes in developing erythroid cells is controlled by upstream locus control regions. Activity of these regions in vivo requires an erythroid-specific nuclear factor (NF-E2) that binds AP-1-like recognition sites. Its tissue-specific component (p45 NF-E2) has been characterized by complementary DNA cloning as a new basic region-leucine zipper protein which dimerizes with a ubiquitous partner to form native NF-E2.

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