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. 1993 Jan 4;149(1):1-5.
doi: 10.1016/0304-3940(93)90332-f.

Growth factor modulation of surface ganglioside expression in cloned neoplastic glia

G J Pilkington  1 , J R Dunan, J P Rogers, T M Clarke, J C Knott
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Growth factor modulation of surface ganglioside expression in cloned neoplastic glia

G J Pilkington et al. Neurosci Lett. .

Abstract

Cloned neoplastic astrocytes from a human glioma-derived cell line (IPSB-18) were grown in fetal calf serum (FCS)-supplemented culture medium in the presence of three growth factors. Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. No such growth factor-mediated induction could be detected in cells maintained in plasma-derived serum (PDS)-supplemented medium. Small molecules, removed from PDS during dialysis, may, therefore, act synergistically with growth factors in the control of ganglioside synthesis.

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