Role of glutathione for cisplatin nephrotoxicity in young and adult rats
- PMID: 8469780
- DOI: 10.3109/08860229309046144
Role of glutathione for cisplatin nephrotoxicity in young and adult rats
Abstract
Investigations were done in 10- and 55-day-old Wistar rats. Glutathione (GSH) level in kidney was decreased by 8 mmol buthionine sulfoximine (BSO)/100 g BW. There was no effect on the renal function and nephrotoxicity of cisplatin (0.6 mg CP/100 g BW) in adult rats. In young rats BSO treatment was followed by nephrotoxic effects. Pt concentration remained unaffected by BSO in young and adult rats. GSH concentration in kidney was increased by 100 mg acetyl-cysteine (accys)/100 g BW. CP nephrotoxicity was lower in young as well as in adult ac-cys-treated rats. Pt levels in renal tissue were significantly decreased in rats from both age groups. From our results we conclude that the beneficial effect of high GSH concentration in renal tissue on CP nephrotoxicity is the result of decreased Pt concentration in kidney.
Similar articles
-
Enhancement of cisplatin toxicity by buthionine sulfoximine, a glutathione-depleting agent, in mice.Res Commun Chem Pathol Pharmacol. 1990 Jan;67(1):131-41. Res Commun Chem Pathol Pharmacol. 1990. PMID: 2326543
-
Effects of buthionine sulfoximine on the nephrotoxicity of 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU).J Pharmacol Exp Ther. 1985 Aug;234(2):498-506. J Pharmacol Exp Ther. 1985. PMID: 4020683
-
Pharmacologic modulation of reduced glutathione circadian rhythms with buthionine sulfoximine: relationship with cisplatin toxicity in mice.Toxicol Appl Pharmacol. 1997 Apr;143(2):281-90. doi: 10.1006/taap.1996.8088. Toxicol Appl Pharmacol. 1997. PMID: 9144445
-
Tissue-specific changes in glutathione and cysteine after buthionine sulfoximine treatment of rats and the potential for artifacts in thiol levels resulting from tissue preparation.Toxicol Appl Pharmacol. 1991 Feb;107(2):269-84. doi: 10.1016/0041-008x(91)90208-v. Toxicol Appl Pharmacol. 1991. PMID: 1994510
-
Interactions of drugs with the developing kidney.Pediatr Clin North Am. 1995 Dec;42(6):1415-31. doi: 10.1016/s0031-3955(16)40091-x. Pediatr Clin North Am. 1995. PMID: 8614593 Review.
Cited by
-
Ameliorative Effect of Daidzein on Cisplatin-Induced Nephrotoxicity in Mice via Modulation of Inflammation, Oxidative Stress, and Cell Death.Oxid Med Cell Longev. 2017;2017:3140680. doi: 10.1155/2017/3140680. Epub 2017 Aug 2. Oxid Med Cell Longev. 2017. PMID: 28831294 Free PMC article.
-
Insights Into Protective Mechanisms of Dandelion Leaf Extract Against Cisplatin-Induced Nephrotoxicity in Rats: Role of Inhibitory Effect on Inflammatory and Apoptotic Pathways.Dose Response. 2019 Sep 12;17(3):1559325819874897. doi: 10.1177/1559325819874897. eCollection 2019 Jul-Sep. Dose Response. 2019. PMID: 35185411 Free PMC article.
-
The effect of treatment with high dose melphalan, cisplatin or carboplatin on levels of glutathione in plasma, erythrocytes, mononuclear cells and urine.Cancer Chemother Pharmacol. 1996;37(5):479-85. doi: 10.1007/s002800050415. Cancer Chemother Pharmacol. 1996. PMID: 8599872
-
Successful treatment of Cisplatin overdose with plasma exchange.Case Rep Med. 2010;2010:802312. doi: 10.1155/2010/802312. Epub 2010 Mar 11. Case Rep Med. 2010. PMID: 20300587 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous
