Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Feb;13(2):321-31.
doi: 10.1016/0090-6980(77)90011-9.

The effect of loperamide on prostaglandin induced diarrhoea in rat and man

S M Karim, P G Adaikan

The effect of loperamide on prostaglandin induced diarrhoea in rat and man

S M Karim et al. Prostaglandins. 1977 Feb.

Abstract

Loperamide, a new antidiarrhoeal compound, effectively antagonised prostaglandin induced diarrhoea in adult healthy male volunteers and in patients undergoing pregnancy termination with prostaglandins. This compound is effective in inhibiting prostaglandin induced fluid accumulation in the small intestine in rats. Loperamide also blocked smooth muscle stimulating action of prostaglandins, acetylcholine and histamine on gastrointestinal smooth muscle preparations from several laboratory animals.

PubMed Disclaimer

MeSH terms

LinkOut - more resources