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. 1977 Apr 15;196(4287):326-8.
doi: 10.1126/science.847477.

Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

D R Burt, I Creese, S H Snyder

Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

D R Burt et al. Science. .

Abstract

Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25% increase in striatal dopamine receptor binding assayed with [3H]haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.

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